Diethyl Oxalate → Ethyl 2-oxo-3-phenylpropanoate

HRID 1508423노트

반응식

F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].C(Br)C1C=CC=CC=1.[Mg].C(OCC)(=O)C(OCC)=O>>[C:3]1([CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

참가 물질

반응물 4

HCID 7268Diethyl Oxalate

HCID 7498Benzyl Bromide

HCID 5462224Magnesium

HCID 18370709Ethyl (2-fluorophenyl)pyruvate

생성물 1

HCID 12292599Ethyl 2-oxo-3-phenylpropanoate수율 80%

실험 절차

The title compound was prepared as described for B4 using benzyl bromide (1.250 g, 7.31 mmol), magnesium (0.195 g, 8.04 mmol) and diethyl oxalate (2.136 g, 14.62 mmol) in the form of colorless oil in 80% yield and used instantly in next step.

출처 및 근거

ORD 기록: ord-52eb95a6d9b74cc5876a983ee0b66d2d
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221860B2

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