Diethyl Oxalate → Ethyl 3-(2-chlorophenyl)-2-oxopropanoate

HRID 1508433노트

반응식

HRID 1508433 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11].[Cl:16]C1C=CC=CC=1CCl.[Mg].C(OCC)(=O)C(OCC)=O>>[Cl:16][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11]

참가 물질

5

반응물 4

HCID 7268Diethyl OxalateHCID 119062-Chlorobenzyl chlorideHCID 5462224MagnesiumHCID 18370709Ethyl (2-fluorophenyl)pyruvate

생성물 1

HCID 18370191Ethyl 3-(2-chlorophenyl)-2-oxopropanoate수율 74%

실험 절차

The title compound was prepared as described for B4 using 2-chlorobenzyl chloride (1.250 g, 7.76 mmol), magnesium (0.208 g, 8.54 mmol), diethyl oxalate (2.269 g, 15.53 mmol). The product was isolated in the form of colorless oil in 74% yield and use instantly in next step.

후처리

  1. customThe product was isolated in the form of colorless oil in 74% yield and use instantly in next step

출처 및 근거

ORD 기록
ord-b31077831152426bb20b4d487dcc08d2
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221860B2

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