Sodium borohydride → HCID 64515792, 화합물

HRID 1508543노트

반응식

HRID 1508543 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10]2)=[CH:5][CH:4]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 140909103-(4-Methoxyphenyl)cyclopentan-1-one

생성물 1

HCID 64515792HCID 64515792, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a RT solution of 3-(4-methoxyphenyl)cyclopentanone (Step B) (482.5 mg, 2.54 mmol) in MeOH (5 ml) was added sodium borohydride (96 mg, 2.54 mmol). The reaction mixture was stirred under nitrogen for 30 minutes, then, concentrated, added water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and the solvent was evaporated under reduced pressure to afford the title compound as a mixture of diastereomers that was used without further purification. Mass spectrum (ESI) 175.3 (M+1 minus 18).

후처리

  1. concentrationconcentrated
  2. additionadded water
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-59762882a45a47dba9bb864048a8fad0
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221834B2

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