Sodium Bicarbonate → 5-Ethyl-4-hydroxy-6-methyl-2(1H)-pyridinone

HRID 1508687노트

반응식

HRID 1508687 반응식
[CH2:1]([C:3]1[C:4]([OH:16])=[C:5](C(OCC)=O)[C:6](=[O:10])[NH:7][C:8]=1[CH3:9])[CH3:2].C([O-])(O)=O.[Na+]>Cl>[CH2:1]([C:3]1[C:4]([OH:16])=[CH:5][C:6](=[O:10])[NH:7][C:8]=1[CH3:9])[CH3:2]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 54706937Ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate

생성물 1

HCID 547073435-Ethyl-4-hydroxy-6-methyl-2(1H)-pyridinone수율 54%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A 50-mL round bottom flask was charged with ethyl 5-ethyl-4-hydroxy-6-methyl-2-oxo-1H-pyridine-3-carboxylate (117 mg, 0.52 mmol) and 1N HCl (10 ml). The mixture was stirred under reflux overnight. After cooling to room temperature, the mixture was neutralized by addition of aqueous NaHCO3 to pH=7. The precipitate was collected by filtration and washed with water. After dried, 5-ethyl-4-hydroxy-6-methyl-1H-pyridin-2-one was obtained (43 mg, 54% yield).

후처리

  1. temperatureunder reflux overnight
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water
  4. customAfter dried

출처 및 근거

ORD 기록
ord-09e5c92ff6ed4a59b3e7a648326768ca
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221843B2

반응 노트

불러오는 중…