Nitrogen → 2-Chloro-4-(5-chloro-2-thienyl)-6-methyl-1,3,5-triazine

HRID 1508701노트

반응식

[Cl:1][C:2]1[S:6][C:5]([C:7](=[NH:11])[NH:8][C:9]#N)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:14].N#N.[CH3:19][C:20]#[N:21]>>[Cl:14][C:9]1[N:8]=[C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:11]=[C:20]([CH3:19])[N:21]=1

참가 물질

반응물 4

HCID 947Nitrogen

HCID 6342Acetonitrile

HCID 24813Phosphorus oxychloride

HCID 178512257HCID 178512257, 화합물

생성물 1

HCID 742210402-Chloro-4-(5-chloro-2-thienyl)-6-methyl-1,3,5-triazine

반응 조건

온도: 70 °C

실험 절차

To a solution of reactant 3 in CH3CN was added reactant 2 and POCl3. The mixture was stirred at 70° C. overnight under. N2. TLC showed starting material was consumed. The mixture was then poured into NaHCO3 (aq) carefully and the precipitate collected. The dried sample was confirmed as desired product 2-chloro-4-(5-chlorothiophen-2-yl)-6-methyl-1,3,5-triazine 4.

후처리

customwas consumed
additionThe mixture was then poured into NaHCO3 (aq) carefully
customthe precipitate collected

출처 및 근거

ORD 기록: ord-3346b58509d749b7a4c3b4f6baa525ec
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221843B2

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