Hydrazinecarboxylic acid, ethyl ester → HCID 178473565, 화합물

HRID 1509136노트

반응식

HRID 1509136 반응식
[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:20][C:21]4[NH:26][C:25](=S)[CH2:24][O:23][C:22]=4[N:28]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[NH:36]([C:38]([O:40][CH2:41][CH3:42])=[O:39])[NH2:37]>C1COCC1>[C:1]([O:5][C:6]([NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[CH:20][C:21]4[NH:26][C:25](=[N:37][NH:36][C:38]([O:40][CH2:41][CH3:42])=[O:39])[CH2:24][O:23][C:22]=4[N:28]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)=[O:35])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 86683631Tert-butyl (1-(4-(7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

생성물 1

HCID 178473565HCID 178473565, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of tert-butyl(1-(4-(7-phenyl-2-thioxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate (20 mg, 0.04 mmol) in dry THF (1 mL) was added ethyl hydrazinecarboxylate (21 mg, 0.20 mmol) and mercuric acetate (21 mg, 0.06 mmol) under nitrogen. The reaction mixture was stirred for 2 h at room temperature, filtered on celite and concentrated to dryness under reduced pressure to give the title compound which was used without purification in the next step.

후처리

  1. filtrationfiltered on celite and
  2. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-3ccca1324a7d4efcbbd04b79ebb13e54
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221838B2

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