Tin atom → 7-Phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

HRID 1509273노트

반응식

HRID 1509273 반응식
[N+:1]([C:4]1[C:5]([O:16][CH2:17][C:18]([O:20]CC)=O)=[N:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:9]=1)([O-])=O.[Sn]>Cl>[C:10]1([C:8]2[CH:7]=[N:6][C:5]3[O:16][CH2:17][C:18](=[O:20])[NH:1][C:4]=3[CH:9]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 5352426Tin atomHCID 67255179Ethyl 2-((3-nitro-5-phenylpyridin-2-yl)oxy)acetate

생성물 1

HCID 669367437-Phenyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
2.5 °C

실험 절차

In a 500 ml round-bottomed flask was added ethyl 2-(3-nitro-5-phenylpyridin-2-yloxy)acetate (4.6 g, 15.22 mmol) in hydrochloric acid, 37% (40 ml) to give a yellow suspension. The mixture was cooled to 0-5° C. followed by the portion wise addition of tin powder (9.94 g, 84 mmol). The addition proved to be exothermic. Caution should be taken while adding. The mixture was then stirred at room temperature for further 30 minutes until all foaming ceased. The reaction mixture was heated to 80° C. under a nitrogen atmosphere for 3 hours.

후처리

  1. customto give a yellow suspension
  2. additionThe addition
  3. additionwhile adding
  4. temperatureThe reaction mixture was heated to 80° C. under a nitrogen atmosphere for 3 hours

출처 및 근거

ORD 기록
ord-f13cf9e9ce16442abb54db50a4d6fd1e
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221838B2

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