Water → Salvinorin B

HRID 1509364

반응식

HRID 1509364 반응식
CC([O:4][C@@H:5]1[C:19](=[O:20])[C@H:18]2[C@@:8]([CH3:27])([CH2:9][CH2:10][C@@H:11]3[C@:17]2([CH3:21])[CH2:16][C@@H:15]([C:22]2[CH:23]=[CH:24][O:25][CH:26]=2)[O:14][C:12]3=[O:13])[C@H:7]([C:28]([O:30][CH3:31])=[O:29])[CH2:6]1)=O.C(=O)([O-])[O-].[Na+].[Na+].O>CO>[CH3:27][C@:8]12[C@H:7]([C:28]([O:30][CH3:31])=[O:29])[CH2:6][C@H:5]([OH:4])[C:19](=[O:20])[C@@H:18]1[C@:17]1([CH3:21])[C@H:11]([C:12]([O:14][C@H:15]([C:22]3[CH:23]=[CH:24][O:25][CH:26]=3)[CH2:16]1)=[O:13])[CH2:10][CH2:9]2

참가 물질

5

반응물 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 128563Salvinorin A

생성물 1

HCID 11440685Salvinorin B수율 42.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of Salvinorin A (500 mg, 1.15 mM) in methanol (10 ml) was added solid sodium carbonate (490 mg, 4.6 mM) and the mixture stirred at room temperature overnight. Water (20 ml) was added to mixture and the mixture stirred for 30 mins. The solution was filtered and the filter-cake washed with ice-cold water (20 ml) and ice-cold methanol (20 ml) and dried in a dessicator to give Salvinorin B (191 mg, 42%).

후처리

  1. stirringthe mixture stirred for 30 mins
  2. filtrationThe solution was filtered
  3. washthe filter-cake washed with ice-cold water (20 ml) and ice-cold methanol (20 ml)
  4. customdried in a dessicator

출처 및 근거

ORD 기록
ord-fde16edeb1b248fdb5fe3b8ab8ff05a5
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09222949B2

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