Thionyl Chloride → Ethyl 3-(chloromethyl)imidazo[1,2-a]pyridine-2-carboxylate hydrochloride
반응식
O[CH2:2][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]2=[N:5][C:4]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].S(Cl)([Cl:19])=O>C(Cl)(Cl)Cl>[ClH:19].[Cl:19][CH2:2][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]2=[N:5][C:4]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]참가 물질
4
실험 절차
To a solution of ethyl 3-(hydroxymethyl)imidazo[1,2-a]pyridine-2-carboxylate (2.85 g) in chloroform (40 ml) was added thionyl chloride (8.0 ml) at room temperature, and the mixture was heated under reflux for 12 hr. The reaction solution was cooled to room temperature, and concentrated under reduced pressure. The precipitated crystals were collected by filtration, washed with diethyl ether to give the object product (3.50 g).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 12 hr
- concentrationconcentrated under reduced pressure
- filtrationThe precipitated crystals were collected by filtration
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-0aa06fbf3d0b4de7b6d2d36624b69d27
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09221836B2
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