Sodium Hydroxide → 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylic acid

HRID 1509593노트

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HRID 1509593 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:9]=[C:8]1[C:18]([O:20]CC)=[O:19].[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:10][CH:9]=[C:8]1[C:18]([OH:20])=[O:19]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58355456ethyl 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 583555721-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylic acid수율 107.7%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

Ethyl 1-(4-methoxybutyl)-5-phenyl-1H-pyrrole-2-carboxylate (430 mg) was dissolved in methanol (2 ml), 2M aqueous sodium hydroxide solution (4 ml) was added and the mixture was stirred at 60° C. for 12 hr. The reaction mixture was concentrated under reduced pressure, and the aqueous layer of the mixture was adjusted to pH 3 with 6M hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the object product (420 mg).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-621414f4c81342558a910879c8041dd2
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221836B2

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