4-Methylmorpholine → Methyl (5-chlorothiophene-2-carbonyl)alaninate

HRID 15097

반응식

HRID 15097 반응식
C[C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[C:8]([OH:10])=O.[NH2:11][CH:12]([CH3:16])[C:13]([O-:15])=[O:14].[CH3:17]N(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>C1COCC1>[Cl:7][C:5]1[S:4][C:3]([C:8]([NH:11][CH:12]([CH3:16])[C:13]([O:15][CH3:17])=[O:14])=[O:10])=[CH:2][CH:6]=1

참가 물질

6

반응물 4

HCID 79724-MethylmorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 5460975AlaninateHCID 133762205-Chloro-3-methylthiophene-2-carboxylic acid

생성물 1

HCID 60638172Methyl (5-chlorothiophene-2-carbonyl)alaninate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.

출처 및 근거

ORD 기록
ord-bb1475882c98444395d60f139ca030c2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732466B2

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