Sodium borohydride → Veonetinib

HRID 1510105노트

반응식

HRID 1510105 반응식
[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][N:27]4[CH2:33][C:32](=[O:34])[C:29]5([CH2:31][CH2:30]5)[CH2:28]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:35])[NH:6]2.[BH4-].[Na+]>CO>[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][CH2:26][N:27]4[CH2:33][CH:32]([OH:34])[C:29]5([CH2:31][CH2:30]5)[CH2:28]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:35])[NH:6]2

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 461764815-(2-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-one

생성물 1

HCID 46176482Veonetinib수율 79.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The above product from Example 2 (75 mg) was dissolved into MeOH (8 ml) and stirred at RT. NaBH4 (75 mg) was added to the reaction and stirred at RT for 30 min. The reaction was evaporated and purified by column chromatography to give title compound (60 mg). Mass: (M+1), 478

후처리

  1. stirringstirred at RT for 30 min
  2. customThe reaction was evaporated
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-b7948eb6f2c34b8abef886925e5ac23b
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211911B2

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