Chloroiodomethane → Methyl 3-cyclopropoxybenzoate
반응식
[CH:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[CH2:2].I[CH2:15]Cl.C([Zn]CC)C>ClC(Cl)C>[CH:1]1([O:3][C:4]2[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=2)[C:7]([O:9][CH3:10])=[O:8])[CH2:15][CH2:2]1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of methyl 3-(vinyloxy)benzoate (0.83 g, 3.99 mmol) in dichloroethane (20 mL) was added iodochloromethane (1.09 mL, 14.9 mmol). The solution was cooled to 0° C. and diethyl zinc (1.0 M in hexanes, 7.48 mL, 7.48 mmol) was added. The cooling bath was removed and the reaction was stirred at rt for 30 min. The reaction mixture was quenched with 1N HCl, extracted with methylene chloride (three times), dried with MgSO4 and concentrate under vacuum to afford the desired product.
후처리
- customThe cooling bath was removed
- customThe reaction mixture was quenched with 1N HCl
- extractionextracted with methylene chloride (three times)
- dry with materialdried with MgSO4
- concentrationconcentrate under vacuum
출처 및 근거
- ORD 기록
- ord-9da18a6a5ae843529c2bb78ba53a0227
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08211904B2
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