Dichloromethane → (3-Isopropoxyphenyl)methanol

HRID 1510151

반응식

HRID 1510151 반응식
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+].C(Cl)Cl>CO>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6344Dichloromethane2회HCID 7129143-IsopropoxybenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 2759474(3-Isopropoxyphenyl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 1 molar solution of 3-isopropoxy benzaldehyde (102 g, 0.621 moles) in methanol (620 mL) cooled to 0° was added (slowly) sodium borohydride powder (25.8 g, 0.683 moles)-dissolved in a minimum of methylene chloride and passed through a plug of silica gel washing with more methylene chloride until the silica gel was free of the product. The eluent was stripped to an oil and pumped on high vacuum overnight.

후처리

  1. custompumped on high vacuum overnight

출처 및 근거

ORD 기록
ord-bb2baadfd4414e958c89bb400d2de812
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08211904B2

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