4-Methylmorpholine → HCID 178428660, 화합물

HRID 15106노트

반응식

HRID 15106 반응식
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[NH2:10][C@H:11]([CH2:29][C:30]1[N:31]=[CH:32][NH:33][CH:34]=1)[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:22])=[C:17]([CH3:28])[CH:16]=1)=[O:13].CN1CCOCC1>C1COCC1>[NH:33]1[CH:34]=[C:30]([CH2:29][C@@H:11]([NH:10][C:7]([C:5]2[S:6][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:9])[C:12](=[O:13])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)=[O:22])=[C:17]([CH3:28])[CH:16]=2)[N:31]=[CH:32]1

참가 물질

5

반응물 3

HCID 79724-MethylmorpholineHCID 3491155-Bromothiophene-2-carboxylic acidHCID 178428662HCID 178428662, 화합물

생성물 1

HCID 178428660HCID 178428660, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to Example 10c from 5-bromo-thiophene-2-carboxylic acid and (R)-2-amino-3-(1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide with PPA and NMM in THF.

출처 및 근거

ORD 기록
ord-999da6e8184f4319ab6c7c3fc944720f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732466B2

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