Lithium Hydroxide → 2-Ethylpyridin-3-ol
반응식
C([O:4][C:5]1[C:6]([CH2:11][CH3:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=O)C.[Li+].[OH-]>C(O)C>[CH2:11]([C:6]1[C:5]([OH:4])=[CH:10][CH:9]=[CH:8][N:7]=1)[CH3:12]참가 물질
4
실험 절차
To a solution of 2-ethylpyridin-3-yl acetate (5.1 g, 31 mmol) in ethanol (50 mL) was added 3M LiOH (50 mL, 150 mmol). The reaction mixture stirred at ambient temperature for 30 minutes. The mixture was concentrated to dryness and purified over silica gel (10% MeOH in CH2Cl2) to afford 2-ethylpyridin-3-ol (2.5 g, 20 mmol).
후처리
- concentrationThe mixture was concentrated to dryness
- custompurified over silica gel (10% MeOH in CH2Cl2)
출처 및 근거
- ORD 기록
- ord-8bfd3a82531f4e92b93367656bc76af4
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08212045B2
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