Acetic Acid → 7-Methoxy-1-naphthaleneethanamine
반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:5][CH:4]=1.[BH4-].[Na+].C(O)(=O)C>CC(O)C.O>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][CH2:14][NH2:15])=[CH:5][CH:4]=1참가 물질
5
실험 절차
In a reactor, 1 g of the compound obtained in Step C and 5 eq. of NaBH4 are introduced into a 2-propanol/water 6/1 mixture, and the mixture is stirred at ambient temperature. Acetic acid (0.2 eq.) is then added and the reaction mixture is heated at 80° C. for 8 hours. After evaporating off the solvents and co-evaporation of water with toluene, the crude residue obtained is used directly in the acetylation reaction without further purification.
후처리
- temperaturethe reaction mixture is heated at 80° C. for 8 hours
- customAfter evaporating off the solvents and co-evaporation of water with toluene
출처 및 근거
- ORD 기록
- ord-35720e78bc4f40a58eb0b5a14acffd80
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08212077B2
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