Formamide → 4-chloroisoindole-1,3-dione
반응식
[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=O)[C:3]=12)=[O:6].C([NH2:15])=O>O>[Cl:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:3]=1[C:8](=[O:7])[NH:15][C:5]2=[O:6]참가 물질
4
반응 조건
- 온도
- 125 °C
실험 절차
A mixture of 3-chlorophthalic acid anhydride (9 g, 49.2 mmol) and formamide (100 mL) was heated to 125° C. and stirred for 3 h. Water (300 mL) was then added and the mixture was cooled to room temperature. The mixture was filtered and the resulting white solid was washed with water and dried to give 4-chloro-1H-isoindole-1,3(2H)-dione (7.7 g, 86% yield).
후처리
- temperaturethe mixture was cooled to room temperature
- filtrationThe mixture was filtered
- washthe resulting white solid was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-1f72a5a000e641f6b622ab01e30fdc42
- 출처 데이터셋
- uspto-grants-2012_07
- 특허 번호
- US08216999B2
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