Triethylamine → HCID 67230608, 화합물

HRID 1511958노트

반응식

HRID 1511958 반응식
C(OC(=O)[N:7]([CH2:13][CH2:14][CH2:15][CH3:16])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)(C)(C)C.C(N(CC)CC)C.[Si](OS(C(F)(F)F)(=O)=O)(C)(C)C>C(Cl)Cl>[CH2:13]([NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)[CH2:14][CH2:15][CH3:16]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 65367Trimethylsilyl triflateHCID 67230193Butyl-pyrrol-1-yl-carbamic acid tert-butyl ester

생성물 1

HCID 67230608HCID 67230608, 화합물수율 113.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of butyl-pyrrol-1-yl-carbamic acid tert-butyl ester (1.435 g), triethylamine (2.06 mL) and TMSOTf (1.79 mL) in DCM was stirred at rt for 15 min. The mixture was then diluted with DCM, washed with water, saturated sodium chloride solution and then dried over sodium sulfate, filtered, concentrated to give the desired product as oil (943 mg). 1H NMR (CDCl3, δ in ppm): 6.74 (m, 2H), 6.04 (m, 2H), 4.9 (very broad, 1H), 3.11 (t, 2H, J=7.1 Hz), 1.44-1.22 (m, 4H), 0.92 (t, 2H, J=7.3 Hz).

후처리

  1. washwashed with water, saturated sodium chloride solution
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-436aa6da1d964e71bc7d9467d259ad47
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217043B2

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