Hydrazine hydrate (1:1) → HCID 59309723, 화합물

HRID 1512988노트

반응식

HRID 1512988 반응식
[Cl:1][C:2]1[C:3]([N:11]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:4][C:5]([SH:10])=[C:6]([O:8][CH3:9])[CH:7]=1.O.NN>O1CCCC1>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([SH:10])=[CH:4][C:3]=1[NH2:11]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 59310058HCID 59310058, 화합물

생성물 1

HCID 59309723HCID 59309723, 화합물수율 77.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-chloro-4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-mercaptoanisole (0.65 g) in tetrahydrofuran (20 mL) was added hydrazine monohydrate (0.5 mL), and the mixture was heated at reflux for 1.5 hours. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane−n-hexane/ethyl acetate=1/1) to give the title compound (0.3 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 1.5 hours
  3. customThe insoluble material was removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel (eluent: n-hexane−n-hexane/ethyl acetate=1/1)

출처 및 근거

ORD 기록
ord-2b7a1a65ef164af5b1452f02e381f2e5
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217069B2

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