[5-(4-Amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine → 4-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine

HRID 1513272노트

반응식

HRID 1513272 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)=[N:10][N:9]=2)=[CH:4][C:3]=1[N+:21]([O-])=O>CO.O=[Pt]=O>[Cl:20][C:16]1[CH:15]=[C:14]([NH:13][C:11]2[O:12][C:8]([C:5]3[CH:4]=[C:3]([NH2:21])[C:2]([NH2:1])=[CH:7][CH:6]=3)=[N:9][N:10]=2)[CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 1

HCID 66966422[5-(4-Amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine

생성물 1

HCID 669663754-[5-(3-Chlorophenylamino)-[1,3,4]oxadiazol-2-yl]-benzene-1,2-diamine

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

A suspension of [5-(4-amino-3-nitrophenyl)-[1,3,4]oxadiazol-2-yl]-(3-chlorophenyl)-amine (245 mg, 0.74 mmol) and PtO2 (50 mg) in MeOH (30 mL) was hydrogenated at one atm for 4 h. The catalyst was filtered over Celite and the filtrate was evaporated under reduced pressure to give the title compound. This was used directly in the next reaction.

후처리

  1. filtrationThe catalyst was filtered over Celite
  2. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-26ac8c49fe894fddb7a8b8e4750028c0
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217065B2

반응 노트

불러오는 중…