Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

반응식

[N:1]1[NH:2][C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:2]1[C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=[N:1]1)(=[O:11])[CH3:10]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 680371,2,4-Triazine-3,5(2H,4H)-dione

생성물 1

HCID 212565952-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

실험 절차

1,2,4-Triazine-3,5(2H,4H)-dione, commercially available from Alfa Aesar (800 mg, 7.07 mmol) was suspended in acetic anhydride (4 ml, 42.4 mmol) and the mixture was refluxed for 2 h. The reaction mixture was then cooled to room temperature and dried under vacuum. The crude product was repeatedly treated with toluene and concentrated under vacuum to give, as a light brown solid, the title compound (1.05 g, 96%) that was used in the next step without purification.

후처리

temperaturethe mixture was refluxed for 2 h
customdried under vacuum
additionThe crude product was repeatedly treated with toluene
concentrationconcentrated under vacuum
customto give, as a light brown solid
customthe title compound (1.05 g, 96%) that was used in the next step without purification

출처 및 근거

ORD 기록: ord-2f3b7bdfec754fffaff09268ae3d5cae
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08217168B2

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