Hydrochloric Acid → 6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione hydrochloride

HRID 1513355노트

반응식

HRID 1513355 반응식
[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[N:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:35]>C(OCC)C>[ClH:35].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]3[CH2:22][C@H:21]4[C@:19]([C:23]5[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=5)([CH2:20]4)[CH2:18]3)[N:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 594960896-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione

생성물 1

HCID 686536986-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

6-(2-fluoro-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione (19.7 mg 0.041 mmol, prepared following an analoguos procedure to that described for Ex9) was diluted in diethyl ether (1 ml) and hydrochloric acid 1M in Et2O (0.045 ml, 0.045 mmol) under nitrogen atmosphere. Solvent was removed and the residue triturated in Et2O (2×1 mL), obtaining 21.8 mg of title compound as a white solid.

후처리

  1. customSolvent was removed
  2. customthe residue triturated in Et2O (2×1 mL)

출처 및 근거

ORD 기록
ord-c9b64724bf9a47e9916d58761274a029
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217168B2

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