Methyl 3-oxovalerate → Methyl (2Z)-3-amino-2-pentenoate

HRID 1513567노트

반응식

HRID 1513567 반응식
O=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].C([O-])(=O)C.[NH4+:14]>CO>[NH2:14]/[C:2](/[CH2:8][CH3:9])=[CH:3]\[C:4]([O:6][CH3:7])=[O:5]

참가 물질

4

반응물 2

HCID 121699Methyl 3-oxovalerateHCID 517165Ammonium Acetate

생성물 1

HCID 21343688Methyl (2Z)-3-amino-2-pentenoate수율 92.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 3-oxovalerate (75.0 g, 576 mmol), ammonium acetate (222 g, 2.88 mol) and methanol (750 mL) was stirred at room temperature for 3 days. The mixture was concentrated under reduced pressure, water (500 mL) was added to the residue and the mixture was extracted with ethyl acetate (200 mL). The extract was washed with brine, dried over magnesium sulfate, concentrated under reduced pressure, and dried to give the title compound (68.5 g, 92%) as a pale-yellow oil.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure, water (500 mL)
  2. additionwas added to the residue
  3. extractionthe mixture was extracted with ethyl acetate (200 mL)
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customdried

출처 및 근거

ORD 기록
ord-9fed9123cc1045a8b0d04c0d41fb45bf
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217176B2

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