Hydrazine hydrate (1:1) → m-Bromobenzohydrazide

HRID 1514004

반응식

HRID 1514004 반응식
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[CH:6]=1)C.O.[NH2:14][NH2:15]>C(O)C>[Br:11][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=1)[C:4]([NH:14][NH2:15])=[O:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 90488Ethyl 3-bromobenzoate

생성물 1

HCID 520941m-Bromobenzohydrazide수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

After 10 grams (44 mmol) of ethyl-3-bromobenzoate were placed into a 200 mL, three-neck flask, 50 mL of ethanol was added thereto and the mixture was stirred; 12 mL of hydrazine monohydrate was added, this mixture was stirred at 78° C. for 5 hours, and the contents of the flask were reacted together. After the reaction was completed, a solid was precipitated out with the addition of water to the reaction solution. The precipitate solid was removed by suction filtration. With the suction-filtered solid being placed into approximately 500 mL of water and washed and a solid removed by suction filtration, 8.1 grams of a white-colored solid, which was the objective of the synthesis process, were obtained at a yield of 86%.

후처리

  1. additionwas added
  2. stirringthis mixture was stirred at 78° C. for 5 hours
  3. customthe contents of the flask were reacted together
  4. customa solid was precipitated out with the addition of water to the reaction solution
  5. customThe precipitate solid was removed by suction filtration
  6. washwashed
  7. customa solid removed by suction filtration, 8.1 grams of a white-colored solid, which
  8. customwere obtained at a yield of 86%

출처 및 근거

ORD 기록
ord-c3be112600ce4a58aee544efac0496bb
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08221904B2

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