Hydrogen Bromide → HCID 59403478, 화합물

반응식

C[O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1.Br>>[OH:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 598978568-Methoxy-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

생성물 1

HCID 59403478HCID 59403478, 화합물수율 117%

반응 조건

온도: 110 °C

실험 절차

A mixture of 8-(methyloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one (Preparation 25) (7.98 g, 41.3 mmol) and hydrobromic acid (100 ml, 1842 mmol) was stirred and heated at 110° C. for 7 hours. Then the reaction mixture was evaporated and azeotroped twice with 150 ml of ethanol to give the title compound (8.66 g) light brown solid which was used without purification. MS (ES) C9H9NO3 requires 179; found 180 [M+H]+.

후처리

customThen the reaction mixture was evaporated
customazeotroped twice with 150 ml of ethanol

출처 및 근거

ORD 기록: ord-8e86bd5396de46cf86608ab125613222
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08222245B2

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