Acetic Acid → HCID 44129296, 화합물

A suspension of ethyl 4-[7-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]butanoate (Preparation 97) (185 mg, 0.371 mmol) in ethanol (3 ml), was treated with 2M sodium hydroxide (0.556 ml, 1.11 mmol) at room temperature overnight to give a colourless precipitate. A further 1-2 mls of ethanol was added and the temperature was raised to 50° C. to complete the reaction. Acetic acid (0.07 ml, 1.22 mmol) was added to the solution and the mixture concentrated. The resultant oily residue was treated with water (ca 3 ml) then stirred at room temperature for 1-2 hr and filtered. The solid was washed with water, then dissolved in methanol and the solvent evaporated. The resultant solid was dried overnight in vacuo at ca 60° C. to give the title compound (153 mgs).