Hydrochloric Acid → 4-(6-methyl-2-pyridinyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2(1H)-pyrimidinone dihydrochloride
반응식
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=5)([CH2:21]4)[CH2:19]3)[C:10](=[O:34])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.[ClH:35].O1CCOCC1>>[ClH:35].[ClH:35].[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]([CH2:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][C@H:22]4[C@:20]([C:24]5[CH:25]=[CH:26][C:27]([C:30]([F:31])([F:32])[F:33])=[CH:28][CH:29]=5)([CH2:21]4)[CH2:19]3)[C:10](=[O:34])[N:9]=2)[CH:5]=[CH:4][CH:3]=1참가 물질
4
반응물 3
생성물 1
실험 절차
4-(6-Methyl-pyridin-2-yl)-1-{4-[(1S,5R)-1-(4-trifluoromethyl-phenyl)-3-aza-bicyclo[3.1.0]hex-3-yl]-butyl}-1H-pyrimidin-2-one was treated with 4N HCl in dioxane (2 eq), to give the title compound.