Benzaldehyde → HCID 66718302, 화합물

HRID 1514725노트

반응식

HRID 1514725 반응식
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=[O:5])C.[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.CC[O-].[Na+].Cl>C(O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:7]1[C:6]([C:4]([OH:3])=[O:5])=[C:10](/[CH:11]=[CH:18]/[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:9][N:8]=1

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 2723922Sodium ethoxideHCID 22309063HCID 22309063, 화합물

생성물 1

HCID 66718302HCID 66718302, 화합물수율 61%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 5-methyl-3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester (3.0 g, 13 mmol) and benzaldehyde (1.32 mL, 13 mmol) in ethanol (20 mL) was added sodium ethylate (0.97 g, 14 mmol) and the reaction mixture was stirred at reflux for 40 min. Aqueous hydrochloric acid (1 M, 14 mL) was added and stirring was continued for 15 min. The precipitate was filtered and dried to afford the title compound (2.3 g, 61%) as an off-white solid. MS: m/e=290.9 [M−H]−.

후처리

  1. temperatureat reflux for 40 min
  2. stirringstirring
  3. filtrationThe precipitate was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-1d92b7294d2a4c45be40e0404742633a
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222246B2

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