Ethyl Acetate → 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylic acid

HRID 1514931

반응식

HRID 1514931 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([C:18]([O:20]C)=[O:19])[CH:12]=2.[OH-].[Na+].C(OCC)(=O)C>C(O)C>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([C:18]([OH:20])=[O:19])[CH:12]=2

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 66966102methyl 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylate

생성물 1

HCID 669653062-(2,6-dimethylphenyl)-1H-indole-6-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of methyl 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylate (490 mg, 1.75 mmol) and 1N sodium hydroxide (3.5 mL, 3.5 mmol) in ethanol (25 mL) was heated at 80° C. for 18 h. The solution was poured into ethyl acetate and extracted with 1N HCl. The organic phase was dried, filtered, and solvent was removed under reduced pressure to afford 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylic acid.

후처리

  1. extractionextracted with 1N HCl
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customsolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-3d0d33c5aa1841219d2ca4c5b428a91e
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222248B2

연결된 노트

불러오는 중…