3,4-Dimethylaniline → 2-(2,6-Dimethylphenyl)-1H-indole-6-carboxylic acid (3,4-dimethylphenyl)-amide

HRID 1514945

반응식

HRID 1514945 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([C:18](O)=[O:19])[CH:12]=2.[CH3:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][C:28]=1[CH3:29])[NH2:25]>>[CH3:21][C:22]1[CH:23]=[C:24]([NH:25][C:18]([C:13]2[CH:12]=[C:11]3[C:16]([CH:17]=[C:9]([C:3]4[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][C:4]=4[CH3:8])[NH:10]3)=[CH:15][CH:14]=2)=[O:19])[CH:26]=[CH:27][C:28]=1[CH3:29]

참가 물질

3

반응물 2

HCID 72483,4-DimethylanilineHCID 669653062-(2,6-dimethylphenyl)-1H-indole-6-carboxylic acid

생성물 1

HCID 669650362-(2,6-Dimethylphenyl)-1H-indole-6-carboxylic acid (3,4-dimethylphenyl)-amide

실험 절차

The title compound was prepared from 2-(2,6-dimethylphenyl)-1H-indole-6-carboxylic acid and 3,4-dimethylaniline analogous to Example 3-4. 1H NMR (CDCl3, 400 MHz): δ 8.38 (s, broad, 1H), 8.08 (s, 1H), 7.84 (s, broad, 1H), 7.69 (d, J=8.3 Hz, 1H), 7.56 (dd, J=8.3, 1.6 Hz, 1H), 7.45 (d, J=2.0 Hz, 1H), 7.37 (dd, J=8.1, 2.3 Hz, 1H), 7.25 (m, 1H), 7.12 (m, 3H), 6.46 (m, 1H), 2.27 (s, 3H), 2.24 (s, 3H), 2.17 (s, 61-1). MS (m/z) 369.2 (M+1), Retention time=1.73 min (Method 10).

출처 및 근거

ORD 기록
ord-922401bab7ab48a38a0979adda8e8da9
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222248B2

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