Sodium Hydroxide → 2-(2,6-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid

HRID 1514970노트

반응식

HRID 1514970 반응식
C[O:2][C:3]([C:5]1[CH:21]=[CH:20][C:8]2[N:9]=[C:10]([C:12]3[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:19])[O:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>CCO>[Cl:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[C:10]1[O:11][C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:21]=[CH:20][C:8]=2[N:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 669656572-(2,6-Dichlorophenyl)-benzooxazole-6-carboxylic acid methyl ester

생성물 1

HCID 53271602-(2,6-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 2-(2,6-dichlorophenyl)-benzooxazole-6-carboxylic acid methyl ester (1.6 g) in EtOH (13 mL) was added 4N NaOH aqueous solution (6.2 mL). The reaction was stirred at 80° C. for 0.5 h. The reaction mixture was concentrated, diluted with water, and treated with Et2O. The aqueous layer was acidified with 1N HCl aqueous solution. The precipitate was filtered, washed with water, and dried in vacuo to give 2-(2,6-dichloro-phenyl)-benzooxazole-6-carboxylic acid as a white solid: MS (m/z) 308.0 (M+1).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additiondiluted with water
  3. additiontreated with Et2O
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-a6e1d48bb0984e01833eba7bdc030ddc
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222248B2

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