Water → Methyl 3-methyl-4-(4-phenylquinazolin-2-ylamino)benzoate

HRID 1515190노트

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HRID 1515190 반응식
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:18][C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][C:20]=1[CH3:29].O>C(O)CCC>[CH3:29][C:20]1[CH:21]=[C:22]([CH:27]=[CH:28][C:19]=1[NH:18][C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)[C:23]([O:25][CH3:26])=[O:24]

참가 물질

5

반응물 3

HCID 962WaterHCID 2736799Methyl 4-amino-3-methylbenzoateHCID 31235822-Chloro-4-phenylquinazoline

생성물 1

HCID 68930376Methyl 3-methyl-4-(4-phenylquinazolin-2-ylamino)benzoate수율 79.6%

시약·촉매·용매 1

HCID 2631-Butanol용매

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온도
160 °C

실험 절차

A mixture of 2-chloro-4-phenylquinazoline (200 mg, 0.83 mmol) and methyl 4-amino-3-methylbenzoate (137 mg, 0.83 mmol) in n-butanol was heated to 160° C. for 1 h and then cooled to rt. Water (10 mL) was added and the product collected by filtration to give the methyl 3-methyl-4-(4-phenylquinazolin-2-ylamino)benzoate (244 mg, 79%), which was dissolved in a 1:1 mixture of water and methanol (10 mL) containing sodium hydroxide (100 mg, 2.5 mmol). The mixture was heated to 60° C. overnight. Ethyl acetate (100 mL) was added and the phases were separated. The aqueous layer was acidified with 10% aqueous hydrochloric acid and extracted with ethyl acetate. The organic extracts were dried over sodium sulfate, filtered and concentrated on a rotary evaporator to give 3-methyl-4-(4-phenylquinazolin-2-ylamino)benzoic acid (188 mg, 80%).

후처리

  1. temperaturecooled to rt
  2. filtrationthe product collected by filtration

출처 및 근거

ORD 기록
ord-e1b33fe27dd742b1a38d49765e7d4a70
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222263B2

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