Methanol → Methyl 2-(4-Bromophenoxymethyl)benzoic Acid

반응식

[OH-].[Na+].[Br:3][C:4]1[CH:21]=[CH:20][C:7]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14]C)=[O:13])=[CH:6][CH:5]=1.[CH3:22]O>>[CH3:22][C:19]1[C:10]([CH2:9][O:8][C:7]2[CH:20]=[CH:21][C:4]([Br:3])=[CH:5][CH:6]=2)=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13]

참가 물질

반응물 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 53995976Methyl 2-((4-bromophenoxy)methyl)benzoate

생성물 1

HCID 68526746Methyl 2-(4-Bromophenoxymethyl)benzoic Acid수율 84%

실험 절차

A 2 mol/L aqueous sodium hydroxide solution (250 mL) was added to a methanol (1 L) solution of methyl 2-(4-bromophenoxymethyl)-benzoate (139 g, 432 mmol), and the mixture was stirred overnight while heating under reflux. Methanol was distilled off under a reduced pressure, and a 6 mol/L hydrochloric acid was added to the residue obtained to precipitate the crystals, and the precipitated crystals were collected by filtration, and sufficiently washed with water. The crystals were dried over phosphorus pentoxide at 50° C., to give 112 g (84%) of the captioned compound.