7-Methylquinoline → 7-Methyl-1,2,3,4-tetrahydroquinoline

HRID 1515332

반응식

HRID 1515332 반응식
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1>CO.[Pd]>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][NH:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 119277-Methylquinoline

생성물 1

HCID 4586807-Methyl-1,2,3,4-tetrahydroquinoline수율 99.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 7-methylquinoline (2.00 g) in methanol (40 ml), 10% palladium on activated carbon (200 mg) was added and stirred overnight under a hydrogen atmosphere (60 psi) at room temperature. After the reaction mixture was filtered through celite, the solvent was distilled off under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluting solvent: n-hexane:ethyl acetate=20:1 to 10:1) to give the titled compound, i.e., 7-methyl-1,2,3,4-tetrahydroquinoline (2.05 g) as a yellow oil.

후처리

  1. filtrationAfter the reaction mixture was filtered through celite
  2. distillationthe solvent was distilled off under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography (eluting solvent: n-hexane:ethyl acetate=20:1 to 10:1)

출처 및 근거

ORD 기록
ord-47db28d475234f448b93f82a61268022
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222417B2

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