Phosgene → (R)-3-(4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)-1,1-dimethylurea hydrochloride

HRID 1515521노트

반응식

HRID 1515521 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([S:20]([CH:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])=[C:6]([C@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)[CH:7]=1.[C:26](=[O:29])(O)[O-].[Na+].C(Cl)([Cl:33])=O.[CH2:35]([N:37](CC)[CH2:38]C)C.Cl.CNC>ClCCl>[ClH:33].[CH:23]([S:20]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:26](=[O:29])[N:37]([CH3:38])[CH3:35])=[CH:7][C:6]=1[C@H:8]1[CH2:12][CH2:11][CH2:10][NH:9]1)(=[O:21])=[O:22])([CH3:24])[CH3:25]

참가 물질

7

반응물 5

HCID 6371PhosgeneHCID 8471TriethylamineHCID 10473Dimethylamine, hydrochlorideHCID 516892Sodium BicarbonateHCID 57942759(R)-tert-butyl 2-(5-amino-2-(isopropylsulfonyl)phenyl)pyrrolidine-1-carboxylate

생성물 1

HCID 68439178(R)-3-(4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)-1,1-dimethylurea hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To 1F (0.25 g, 0.68 mmol) in dichloromethane (5 mL) at 0° C. was added sodium bicarbonate (0.57 g, 6.8 mmol), then phosgene (0.71 mL, 1.36 mmol, 20% in toluene). The reaction was stirred at 0° C. for 30 min. The crude mixture was filtered and washed with dichloromethane. To the filtrate was added triethylamine (0.27 mL, 2.04 mmol), then dimethylamine hydrochloride (0.083 g, 1.02 mmol) and the reaction was stirred for 2 h at rt. The solution was washed with water and brine and dried over sodium sulfate. The solvent was removed and the residue was redissolved in ethyl acetate (2 mL). HCl (4 mL, 4M in dioxane) was added and the reaction was stirred at rt for 4 h. The solvent was removed and dried under high vacuo to give 31A. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.23 (d, J=6.59 Hz, 3H) 1.31-1.40 (m, 3H) 2.14-2.27 (m, 1H) 2.29-2.43 (m, 2H) 2.44-2.60 (m, 1H) 3.02-3.11 (m, 6H) 3.37-3.53 (m, 3H) 5.42 (t, J=7.69 Hz, 1H) 7.64 (dd, J=8.79, 1.76 Hz, 1H) 7.91 (d, J=8.79 Hz, 1H) 8.08 (d, J=2.20 Hz, 1H).

후처리

  1. filtrationThe crude mixture was filtered
  2. washwashed with dichloromethane
  3. washThe solution was washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed
  6. dissolutionthe residue was redissolved in ethyl acetate (2 mL)
  7. additionHCl (4 mL, 4M in dioxane) was added
  8. stirringthe reaction was stirred at rt for 4 h
  9. customThe solvent was removed
  10. customdried under high vacuo

출처 및 근거

ORD 기록
ord-4be72812c2574ce490c0298ae69e54e0
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222453B2

반응 노트

불러오는 중…