Chloroacetic Acid → N,N-Diethylglycine

HRID 1516136

반응식

HRID 1516136 반응식
Cl[CH2:2][C:3]([OH:5])=[O:4].[CH2:6]([NH:8][CH2:9][CH3:10])[CH3:7]>>[CH2:6]([N:8]([CH2:2][C:3]([OH:5])=[O:4])[CH2:9][CH3:10])[CH3:7]

참가 물질

3

반응물 2

HCID 300Chloroacetic AcidHCID 8021Diethylamine

생성물 1

HCID 74151N,N-Diethylglycine수율 104.8%

실험 절차

A solution of chloroacetic acid (30 g, 0.32 mol) in diethylamine (230 mL, 2.2 mol) was stirred overnight. The obtained white precipitate was removed by filtration. The filtrate was evaporated to dryness to afford yellow oil to which EtOAc (300 mL) was added. The obtained precipitate was again removed by filtration. The filtrate was evaporated to afford yellow solid residue (44 g) that was washed with hexane (2×100 mL), EtOAc (2×50 mL) and again with hexane (50 mL), and then dried in vacuo to afford title Intermediate 2 (38 g).

후처리

  1. customThe obtained white precipitate was removed by filtration
  2. customThe filtrate was evaporated to dryness
  3. customto afford yellow oil to which EtOAc (300 mL)
  4. additionwas added
  5. customThe obtained precipitate was again removed by filtration
  6. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-c050af519d4d4415a82bd6b1297327ed
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227428B2

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