Hydrazine hydrate (1:1) → HCID 178514432, 화합물

반응식

C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>>[O:11]([C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:19][NH2:20])=[O:2])[CH2:6][CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 178501257HCID 178501257, 화합물

생성물 1

HCID 178514432HCID 178514432, 화합물

반응 조건

온도: 120 °C

실험 절차

A mixture of trans-4-phenoxy-cyclohexanecarboxylic acid methyl ester (1.07 g, 4.57 mmol) and hydrazine hydrate (0.22 g, 4.48 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the reaction mixture was concentrated in vacuo to give the crude title compound as white solid in quantitative yield, which was used in the next step without further purification.

후처리

temperatureAfter cooling to room temperature the reaction mixture
concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록: ord-c8e9c8d73b7c4d04afb76377e71d9390
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08227458B2

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