Sodium Chloride → 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

HRID 1517223

반응식

HRID 1517223 반응식
[CH3:1][CH2:2][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:11]([CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=1[CH3:16])=[O:8])[CH2:4][CH3:5].Cl.[Na].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26].[Na+].[Cl-].C(Cl)(Cl)Cl>CO>[CH3:5][CH2:4][N:3]([CH2:6][C:7]([NH:9][C:10]1[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17])=[O:8])[CH2:2][CH3:1].[CH3:20][CH2:21][CH2:22][CH2:23][CH:24]([CH2:27][O:28][C:29]([CH2:31][CH:32]([S:44]([OH:47])(=[O:46])=[O:45])[C:33]([O:35][CH2:36][CH:37]([CH2:40][CH2:41][CH2:42][CH3:43])[CH2:38][CH3:39])=[O:34])=[O:30])[CH2:25][CH3:26]

참가 물질

6

반응물 4

HCID 5234Sodium Chloride2회HCID 6212Chloroform2회HCID 6314Lidocaine HydrochlorideHCID 9955175Sodium docusate

생성물 1

HCID 177558781,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Lidocaine hydrochloride (0.0188 mol) was dissolved in 50 mL methanol and sodium docusate [bis(2-ethylhexyl)sulfosuccinate sodium salt] (0.0188 mol) was dissolved in 50 mL. The two solutions were combined and stirred for two hours, during this time a white precipitate (NaCl) formed. The methanol was removed by rotary evaporation which leaves a white sticky solid. To this solid, 150 mL of chloroform was added. A portion of the product dissolved the chloroform while the byproduct (NaCl) remained as a suspended solid. The NaCl was removed by filitration, and the solvent was removed by rotary evaporation. The product, lidocaine docusate, is a colorless syrup and is dried under high vacuum. 1H and 13C NMR (CDCl3) were obtained.

후처리

  1. customformed
  2. customThe methanol was removed by rotary evaporation which
  3. customleaves a white sticky solid
  4. customThe NaCl was removed by filitration
  5. customthe solvent was removed by rotary evaporation
  6. customis dried under high vacuum
  7. custom1H and 13C NMR (CDCl3) were obtained

출처 및 근거

ORD 기록
ord-78cd1f5ba64544ea9ff536906c2385a6
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232265B2

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