Bromine → 7-Bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde
반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.S([O-])([O-])(=O)=S.[Na+].[Na+]>[Br:17][C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=1참가 물질
6
실험 절차
To a solution of 2,3-dihydro-1-benzofuran-5-carbaldehyde (1.0 g, 6.75 mmol) in glacial acetic acid (8 ml) was added sodium acetate (664 mg, 8.1 mmol) and bromine (0.7 ml, 13.5 mmol) at 10° C. slowly. The reaction was stirred for 2 h at room temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 ml), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%).
후처리
- washwashed with a saturated aqueous solution of sodium bicarbonate
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulfate
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-ccbd064e0acc467fae69302d4fe79d5f
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732460B2
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