Acetic Acid → HCID 136389259, 화합물

HRID 1517394노트

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HRID 1517394 반응식
[NH2:1][C:2]1[NH:3][C:4](=[O:22])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[C:23](O)(=[O:25])[CH3:24]>C(OC(=O)C)(=O)C>[C:23]([NH:1][C:2]1[NH:3][C:4](=[O:22])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1)(=[O:25])[CH3:24]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 1362700182-Amino-6-(3,4-dimethoxyphenyl)pyrido[3,2-d]pyrimidin-4(1H)-one

생성물 1

HCID 136389259HCID 136389259, 화합물수율 77%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

2-amino-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidin-4(3H)-one (2.0 g, 6.70 mmol) was suspended in acetic anhydride (180 ml) and acetic acid (20 ml) and the mixture was refluxed for 16 hours. The hot suspension was filtered and the filtrate was concentrated under reduced pressure until crystallization started. The precipitate was filtered off to give the pure title compound (1.76 g, yield 77%) which was characterized by its mass spectrum as follows: MS (m/z): 341 ([M+H]+, 100).

후처리

  1. filtrationThe hot suspension was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure until crystallization
  3. filtrationThe precipitate was filtered off

출처 및 근거

ORD 기록
ord-02c12462fd6440788eed3d0c757f861e
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232278B2

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