N-(8-phenyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-2-yl)-acetamide → 8-PHENYL-4,5-DIHYDRO-THIAZOLO[4,5-h]QUINAZOLIN-2-YLAMINE

HRID 1517669노트

반응식

HRID 1517669 반응식
[C:1]1([C:7]2[N:16]=[CH:15][C:14]3[CH2:13][CH2:12][C:11]4[N:17]=[C:18]([NH:20]C(=O)C)[S:19][C:10]=4[C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>Cl>[C:1]1([C:7]2[N:16]=[CH:15][C:14]3[CH2:13][CH2:12][C:11]4[N:17]=[C:18]([NH2:20])[S:19][C:10]=4[C:9]=3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 1

HCID 57417111N-(8-phenyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-2-yl)-acetamide

생성물 1

HCID 577412698-PHENYL-4,5-DIHYDRO-THIAZOLO[4,5-h]QUINAZOLIN-2-YLAMINE

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

9.0 g (28 mmol) N-(8-phenyl-4,5-dihydro-thiazolo[4,5-h]quinazolin-2-yl)-acetamide (prepared analogously to Example 64) are refluxed for 2 hours in 130 ml semi-concentrated hydrochloric acid. After cooling the reaction mixture is made basic, the precipitate formed is suction filtered and dried. Yield: 7.3 g

후처리

  1. temperatureAfter cooling the reaction mixture
  2. customthe precipitate formed
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-f3439b84b9c2480da42b031a2893c0ad
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232286B2

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