Hydrochloric Acid → Hydrochloric Acid

To a solution of tert-butyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxypropyl)thiazole-4-carboxylate (38E) (68 mg, 0.1 mmol) in DCM (2 mL) was added 2 mL of 2N HCl in ether. The mixture was stirred at rt overnight. MeOH (0.5 mL) was added to the mixture to dissolve the solid. The mixture was stirred at rt for another 2 hours. The reaction mixture was concentrated under reduced pressure to provide the desired product as an HCl salt: 1H NMR (300 MHz, DMSO-D6) δ ppm 8.03 (1H, d), 7.79 (1H, d), 7.67 (1H, d), 7.41 (5H, m), 4.83 (2H, s), 3.73 (4H, t), 3.50 (2H, t), 3.41 (2H, t), 3.04 (4H, t), 1.69 (2H, m). MS (ESI(+)): m/z 495 (M+H).

1. dissolutionto dissolve the solid
2. stirringThe mixture was stirred at rt for another 2 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure

ORD 기록

ord-7880a9b81d3e495999536b83d0fe826d

출처 데이터셋

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08232273B2