Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylpiperazine → 3-(4-Methylpiperazin-1-yl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylpiperazine | HCID 7096 | — |
| 반응물 | 1-(3-Hydroxyphenyl)piperazine | HCID 2736597 | — |
| 반응물 | methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate | HCID 59447670 | — |
| 반응물 | HCID 178499107 | HCID 178499107 | — |
| 생성물 | 3-(4-Methylpiperazin-1-yl)phenol | HCID 11011455 | — |
반응 단계
Compound 87A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 45C and phenylpiperazine with paraformahyde and 3-(piperazin-1-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 9.07 (s, 1H), 6.94-6.98 (m, 1H), 6.36 (d, J=8.13, 2.4 Hz, 2H), 8.28-8.29 (m, 1H), 6.18-6.21 (m, 1H), 3.04-3.07 (m, 4H), 2.41-2.43 (m, 4H), 2.21 (s, 3H). ESI (+)/MS: 193 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08232273B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-1db435a09d5f493fa91f3a03b4cfc019 |
| 출처 메모 | uspto-grants-2012_07 |