2-(Dimethylamino)ethanol → 2-(3-(benzyloxy)phenoxy)-N,N-dimethylethanamine

반응식

NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(O)=CC=2)C=1C#N.[CH3:23][N:24]([CH3:28])[CH2:25][CH2:26][OH:27].[CH2:29]([O:36][C:37]1[CH:38]=[C:39](O)[CH:40]=[CH:41][CH:42]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:29]([O:36][C:37]1[CH:42]=[C:41]([CH:40]=[CH:39][CH:38]=1)[O:27][CH2:26][CH2:25][N:24]([CH3:28])[CH3:23])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

참가 물질

반응물 3

HCID 79022-(Dimethylamino)ethanol

HCID 138048Benzyl 3-hydroxyphenyl ether

HCID 136027725tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate

생성물 1

HCID 594475752-(3-(benzyloxy)phenoxy)-N,N-dimethylethanamine

실험 절차

Compound 113A was prepared in a similar manner to the synthesis of step 1 of Example 35 by substituting compound 34D and compound 31F with 2-(dimethylamino)ethanol and 3-(benzyloxy)phenol, respectively: DCI (+)MS: 272 (M+H)+.

출처 및 근거

ORD 기록: ord-e085dc17c5ac429fa2e4f8374ba75308
출처 데이터셋: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08232273B2

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