Diisopropylethylamine → 5-Chloro-6-(1-cyclopropylpiperidin-4-ylamino)pyridine-3-sulfonamide

HRID 1518881노트

반응식

HRID 1518881 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1[NH:22][CH:19]1[CH2:20][CH2:21][N:16]([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH2:18]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 47309215,6-Dichloropyridine-3-sulfonamideHCID 162276441-Cyclopropylpiperidin-4-amine

생성물 1

HCID 671692335-Chloro-6-(1-cyclopropylpiperidin-4-ylamino)pyridine-3-sulfonamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of EXAMPLE 387A (0.4 g), 1-cyclopropylpiperidin-4-amine (0.3 g) and N,N-diisopropylethylamine (0.37 mL) in dioxane (3 mL) was heated at 100° C. for 18 hours. The crude product was isolated by concentration and was purified on silica gel, which was eluted with ethyl acetate to give the title compound.

후처리

  1. customThe crude product was isolated by concentration
  2. customwas purified on silica gel, which
  3. washwas eluted with ethyl acetate

출처 및 근거

ORD 기록
ord-5f8b79da0bba45abbd8d00d01069f7ce
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09072748B2

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