Pyridine → HCID 86694483, 화합물
반응식
[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([O:12][CH:13]([F:15])[F:14])[CH:5]=1)[CH:2]=C.N1C=CC=CC=1.[O:22]=[O+][O-]>C(Cl)Cl.CO>[F:14][CH:13]([F:15])[O:12][C:6]1[CH:5]=[C:4]([CH2:1][CH:2]=[O:22])[CH:11]=[CH:10][C:7]=1[C:8]#[N:9]참가 물질
5
반응 조건
- 온도
- -78 °C
실험 절차
A solution of 4-allyl-2-(difluoromethoxy)benzonitrile (600 mg, 2.9 mmol) in 1:1 CH2Cl2/MeOH (15 mL) containing pyridine (0.5 mL, 6 mmol) was cooled to −78° C., and O3 was passed through until a blue color was present. N2 was then bubbled through to discharge the blue color and Me2S (5 ml) was added. The reaction mixture was allowed to warm and left overnight. The mixture was washed with 1 N HCl, aqueous NaHCO3, dried and concentrated to give crude 2-(difluoromethoxy)-4-(2-oxoethyl)benzonitrile.
후처리
- customN2 was then bubbled through
- additionwas added
- temperatureto warm
- washThe mixture was washed with 1 N HCl, aqueous NaHCO3
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-6b9fb73dc52842eeaac7b46cdc55eff2
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09073882B2
반응 노트
불러오는 중…