Hydrazine hydrate (1:1) → 5-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

HRID 1519826

반응식

HRID 1519826 반응식
[Cl:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.O.[NH2:13][NH2:14]>C(O)C>[Cl:1][C:2]1[C:10]2[C:9]([NH:13][NH2:14])=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 157457684,5-Dichlorothieno[2,3-d]pyrimidine

생성물 1

HCID 157460705-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-Chloro-4-chlorothieno[2,3-d]pyrimidine (1.38 g, 6.73 mmol) and hydrazine monohydrate (5.0 ml, 103 mmol) in absolute ethanol (20 ml) were heated at 75° C. After stirring for 24 h, the solution was concentrated to yield 5-chloro-4-hydrazinylthieno[2,3-d]pyrimidine. Method [6] Retention time 0.35 min by HPLC (M+=201 and 203).

후처리

  1. concentrationthe solution was concentrated

출처 및 근거

ORD 기록
ord-e4b54cecd478409b9261bb79a231ca6c
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073891B2

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