Hydrochloric Acid → Methyl 5-amino-1,3-thiazole-4-carboxylate

HRID 1519955노트

반응식

HRID 1519955 반응식
Cl.C1(C(=[N:15][C:16]2[S:20][CH:19]=[N:18][C:17]=2[C:21]([O:23][CH3:24])=[O:22])C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:15][C:16]1[S:20][CH:19]=[N:18][C:17]=1[C:21]([O:23][CH3:24])=[O:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86649429HCID 86649429, 화합물

생성물 1

HCID 53408092Methyl 5-amino-1,3-thiazole-4-carboxylate수율 71.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Aqueous 3N HCl (1 mL) was added to a solution of methyl 5-(diphenylmethyleneamino)thiazole-4-carboxylate (1.22 g, 3.81 mmol) in THF (5 mL). The reaction mixture was stirred for 1 h and the white solid which had formed was isolated by filtration to give methyl 5-aminothiazole-4-carboxylate (0.527 g, 2.72 mmol, 71%). Retention time (min)=0.422, method [7], MS(ESI) 159.0 (M+H).

후처리

  1. customthe white solid which had formed
  2. customwas isolated by filtration

출처 및 근거

ORD 기록
ord-c2f8adf109f5466893cd8b1e09bbf8d7
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073891B2

반응 노트

불러오는 중…