Sodium hydride → tert-butyl 3-{1-[4-(methoxycarbonyl)phenyl]-1H-1,2,3-triazol-4-yl}-5-[(6-oxo-3-pyridin-4-ylpyridazin-1(6H)-yl)methyl]-1H-indazole-1-carboxylate

반응식

[H-].[Na+].[N:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.Br[CH2:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[N:23]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[N:22]=[C:21]2[C:34]1[N:35]=[N:36][N:37]([C:39]2[CH:44]=[CH:43][C:42]([C:45]([O:47][CH3:48])=[O:46])=[CH:41][CH:40]=2)[CH:38]=1.C([O-])(O)=O.[Na+]>CN(C=O)C>[CH3:48][O:47][C:45]([C:42]1[CH:43]=[CH:44][C:39]([N:37]2[CH:38]=[C:34]([C:21]3[C:20]4[C:24](=[CH:25][CH:26]=[C:18]([CH2:17][N:13]5[C:12](=[O:15])[CH:11]=[CH:10][C:9]([C:6]6[CH:7]=[CH:8][N:3]=[CH:4][CH:5]=6)=[N:14]5)[CH:19]=4)[N:23]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[N:22]=3)[N:35]=[N:36]2)=[CH:40][CH:41]=1)=[O:46]